Chapter 19 Miscellaneous conditions

19.1 Myeloma

MYRE (2017): - high-cuttoff dialyser vs. conventional dialyser in myeloma cast nephropathy. No difference in dialysis-independence at 3 months.

EuLITE (2019): - HCO vs. conventional dialysis in cast nephropathy requiring dialysis: open-label, phase 2 trial. All patients treated with bortezomib-based regime. No significant difference in the primary outcome of dialysis-independence at 90 days.

19.2 Pregnancy

TOCOS (2015): - risk factors for adverse pregnancy outcomes in CKD.

Hladunewich et al. (2014): - pregnancy outcomes in women with ESRF receiving intensive dialysis (Toronto cohort) compared to a comparitor cohort receiving conventional dialysis. Fetal outcomes were better in the intensive dialysis group.

CHIPS (2015): - tight (target DBP <85 mmHg) vs. less tight (DBP <100 mmHg) ABP control in pregnant women with non-proteinuric HTN. No difference in maternal and fetal outcomes; less severe hypertension in the tight control group.

Harel et al. (2019): - normal range for SCr in pregnancy.

19.3 AIN

Gonzalez et al. (2008): - retrospective analysis of drug-induced interstitial nephritis. Early treatment with steroids was associated with better renal recovery.

19.4 Tuberous sclerosis

Bissler et al. (2008): - Open label trial of sirolimus with angiomyolipomata (in TSC or sporadic lymphangioleiomyomatosis). Angiomyolipoma volume decreased during sirolimus treatment.

19.5 Other

Groopman et al. (2019): - Exome-sequencing of ~3000 patients with CKD (including ~280 patients with unknown aetiology). Diagnostic variants were detected in ~9% of the whole cohort / 17% of patients with unknown aetiology of CKD / 24% of patients with congenital or cystic disease. Commonest variants in PKD1/2, COL4A3/4/5, UMOD.