Chapter 9 CKD-MBD

9.1 Cinacalcet

EVOLVE (2012): - cinacalcet vs. placebo in CKD5D. No significant difference in primary outcome (cardiovascular disease composite) over ~20 months.

9.2 Phosphate binders

Do calcium-containing binders cause worse hard outcomes?

DCOR (2007): - sevelamer vs. calcium-based binders. No difference in overall mortality.

Jamal et al. (2013): - meta-analysis of 11 RCTs comparing calcium-based with non-calcium-based phosphate binders. Non-calcium-based binders had lower all-cause mortality (RR 0.78, 0.61–0.98).

LANDMARK (2021): - Lanthanum vs. calcium in HD patients (n = 2300 over ~3 yrs). No benefit on primary endpoint of composite CVS events.